Cryopreserved Pre-infected HBV Primary Human Hepatocytes
HepaCur HBVgo™ pre-infected HBV hepatocytes offer an unparalleled in vitro solution for HBV researchers. Skip the infection set-up and donor qualification.
Spend your valuable time focused on therapeutic discovery. From freezer to findings, get going with HBVgo™
Testimonials
"The [HBVgo] hepatocytes performed as well as fresh primary human hepatocytes in our hands and enabled us to do research we otherwise couldn’t have done"
Professor at an HBV research institute
How HBVgo™ Pre-Infected HBV Hepatocytes works
FRG® liver-humanized mice are chronically infected with HBV before hepatocytes are isolated and cryopreserved. We ship frozen HBVgo to your site, so they’re in your freezer and ready when you are. Simply thaw, plate, and in 12 hours, cells are ready for test article administration. If you’re running multiple experiments over time, rest assured, HBVgo hepatocytes are produced with consistency in mind to minimize experiment to experiment variability.
Advantages of HBVgo™
HBVgo delivers pre-infected HBV hepatocytes, removing the delay and variability of establishing infection in-house.
Longer therapeutic window
Skip the time needed to establish HBV infections; start testing treatment response sooner.
Consistent, chronic-level infection, right from plating
>90% of hepatocytes infected starting from day 1.
Built for therapeutic testing
Supports long-term antiviral response and rebound testing, over weeks, not days.
See the data
See the biology behind the number.
Culture progression
Day 1 → Day 39
Day 1 → Day 39
Brightfield
Day 1
Day 7
Day 13
Day 22
Day 30
Day 39
HBcAg
Day 1
Day 7
Day 13
Day 22
Day 26
Day 30
Viral Kinetics & Biomarkers
6 metrics tracked over time
6 metrics tracked over time
HBV titer
HBV genomes per cell
HBsAg
HBeAg
cccDNA
Human albumin
Therapeutic validation
Entecavir & Interferon · 12 graphs
Entecavir & Interferon · 12 graphs
Entecavir
HBV titer
Intracellular HBV DNA
HBsAg
HBeAg
cccDNA
Human albumin
Interferon (25nM)
HBV titer
Intracellular HBV DNA
HBsAg
HBeAg
cccDNA
Human albumin
Faq
What is the typical delivery timeline?
HBVgo cells are ready to ship from our cryofreezer to yours. Standard delivery time is 1-2 weeks from placing your order.
How many cells come in one vial?
Each HBVgo cryovial contains approximately 3M viable human hepatocytes.
Do I need to use special media to culture HBVgo hepatocytes?
No, HBVgo hepatocytes are designed to work with standard hepatocyte culture media (HCM). A cell handling guide is included with each order to provide technical recommendations.
Do you have multiple donors available?
Yes, HBVgo hepatocytes can be made with most of our FRG liver-humanized mice donors. We currently have male and female donors available. Please contact us to learn more about our donor options.
Can Yecuris run a study using the HBVgo hepatocytes for me?
Yes, we are set up to run in vitro studies using HBVgo hepatocytes at our facility in Portland, Oregon. Contact us using the form below to speak with a Yecuris scientist about your project today.
Could you generate HBVgo hepatocyte lots on a custom basis?
Yes, we can generate a custom lot of HBVgo hepatocytes with your HBV genotype, preferred donor or after in vivo treatment. This process typically takes between 12-20 weeks depending on the customization. Please contact us using the form below to speak with a Yecuris scientist about your project.
Talk to a Yecuris Scientist Today
Contact us for more information or to place an order.